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 N E W S C E N T E R
Updated:  Jun 20, 2013
Correlations between mean platelet volume, glycemic control and micro and macrovascular complications in type 2 diabetics
A significant correlation of mean platelet volume existed with fasting glucose and HbA1c in men, whereas mean platelet volume in women had significant correlation with HbA1c.
A reduced incidence of diabetes in association with statin therapy that can relate to statin therapy per se or to accompany a life style management
A significantly higher risk of development of diabetes had been reported amongst patients with prior statin therapy (at baseline or before) and without a record of statin use thereafter vs. those without statin use.
An intensive insulin therapy with low glycemic variability and low exposure to hyperglycemia in patients undergoing cardiac surgery vs. an intensive insulin therapy with high glycemic variability and exposure to hyperglycemia
Despite similar rates of severe hypoglycemia, an intensive insulin therapy with low glycemic variability and low exposure to hyperglycemia to a sustained survival benefit in patients undergoing cardiac surgery for upto 12 months than an intensive insulin therapy with high glycemic variability and exposure to hyperglycemia.
Efficacy of high-selective beta-blocker nebivolol on the clinical outcome, hemodynamic, protein spectrum of urine and renal function in heart failure patients with preserved systolic function and renal dysfunction
A significant increase in levels of microalbuminuria, alpha 1-acid glycoprotein and fibronectin had been reported whereas a significant decrease in creatinine level and frequency of recording endothelium dependent vasodilation had been observed in both groups.
Evaluation of cardiovascular risk markers in male type 2 diabetics with normal and low testosterone levels
In comparison to normal total testosterone, those with low total testosterone have higher levels of IMT, atherosclerotic plaques, endothelial dysfunction, C reactive protein.
 LAST 6 DAYS NEWS
Risk factors associated with an elevated non-HDL-C in diabetic adolescents
Low levels of HbA1c were reported in adolescent diabetics with normal and a borderline non-HDL-C than those with high non-HDL-C.
A low dietary sodium intake by hypertensives during RAAS-blocking therapy results in a marked reduction of BP via decreased urinary albumin excretion
The highest effect of a lowered sodium intake on the reduction of urinary albumin excretion was reported among the hypertensive cohorts employed on a concomitant RAAS-blocking therapy (urinary albumin excretion; -37.1%; -56.1 to -18.2). Moreover, associations existed between 1 mm Hg change in SBP/DBP & changes in urinary albumin excretion of 5.8% and 6.0% respectively.
Type 2 diabetics with microalbuminuria have high cardiovascular risk vs. without microalbuminuria
Significantly higher levels of left ventricular mass index, intima media thickness, BMI, systolic blood pressure and duration of diabetes had been reported in diabetics with microalbuminuria vs. those without.
Altered Cardiovascular Risk by Vitamin D Therapy in Patients under Particular Anti-Diabetic Regimens
Significant improvement in concentrations of circulating 25-hydroxyvitamin D in both diabetics and non-diabetics.
Efficacies of sitagliptin and vildagliptin monotherapies on the systemic inflammation, inflammatory like phenotypes of peripheral blood monocytes and arterial stiffness among type 2 diabetics
A significant reduction in the cardio-ankle vascular index was reported with the Vildagliptin treatment while 3 months of sitagliptin therapy did not reduce it significantly but led to significant reductions in serum levels of inflammatory markers and increase in serum interlukin-10, an anti-inflammatory cytokine, plasma GLP-1.
Association of left ventricular diastolic dysfunction with 24-hour ambulatory central blood pressure among hypertensives
24h aortic BP was superior to any other BP in association with left ventricular diastolic dysfunction.
Prevalence & the factors associated to ‘white-coat’ hypertension & masked hypertension in hypertensives with kidney disease
To assess the prevalence and determinants of ‘white-coat’ hypertension (WCH) and masked hypertension (MH) in hypertensive patients with kidney disease.
Heart rate variability and atrial fibrillation risk among hypertensives
Recently diagnosed hypertensive patients have reduced heart rate variability. Moreover, certain heart rate variability measures like SSNN, LF, and LF/HF ratio correlate with the risk of atrial fibrillation in the medium term.
Impact of impaired renal function with chronic heart failure patients
Subclinical renal dysfunction was detected in CHF patients alone and in CHF accompanied by CKD.
Relationship between number of metabolic syndrome criteria and evidence of subclinical atherosclerosis among obese hypertensives
Significant differences in the atherosclerotic burden in relation with an increasing number of MS components were not observed in patients with hypertension and obesity, although there was as a difference concerning the severity of hypertension in the groups with 4 or 5 criteria of metabolic syndrome.
Impact of Insomnia on the nocturnal BP amongst the very elderly
In patients aged >90 yrs, a reverse sleep-wake rhythm is associated with a non-dipping profile of BP, especially in hypertensives. Moreover, insomnia is not correlated to an augmentation of average values of BP.
Prevalence and treatment of dysmetabolism in elderly hypertensive patients: evidence for inadequate control of metabolic cardiovascular risk factors
The elderly and the very elderly should be managed more “aggressively” to reduce cardiovascular risk & lower the incidences of cerebrovascular events & dementia, allowing a real “active longevity”.
Age dependent changes in central systolic blood pressure levels among hypertensives
There existed a significant correlation between age and central systolic blood pressure levels. Central systolic blood pressure levels were increased with age.
Comparison of 2 therapeutic combinations of ARB with diuretic: focus on the uric acid
Difference in increasing uric acid level by the combinatorial difference of ARB with Diuretics plays a significant role as up regulation of uric acid is an independent risk factor for cardiovascular disease.
Effect of target blood pressure achieved during combined therapy on nocturnal hypertension, glycemic control and intra-renal vascular resistance in hypertensive diabetic patients
A long-term ACE inhibitor + CCB therapy is superior to ARB + CCB therapy, concerning metabolic and neuro-humoral regulation, while CCB + BB therapy does not adequately correct nocturnal systolic hypertension and has no positive effect on renal hemodynamics.
Association of Adipokines with target organ damage among resistant hypertensives
Adiponectin was associated with arterial stiffness and renal injury in the uncontrolled resistant hypertension patients. Moreover, leptin was associated with arterial stiffness.
Clinical features associated with the non-dipping blood pressure profile amongst hypertensives with metabolic syndrome
The ND revealed higher IMT. HDL was significantly lower in the ND group. Col, TG, CRP and Fb and the parameters of arterial stiffness were similar.
Association of cardiovascular risk factors amongst obese hypertensives with different degrees of hypertension
In patients with 3rd degree of hypertension, there existed associations between levels of apo B and TC, LDL-C, VLDL-C and TG as well as negative associations with levels of apoA1 and TC and apo B.
Evaluations of office and 24 hr Ambulatory blood pressure in Drug-resistant hypertension and Obstructive sleep apnea syndrome
patients without sleep-disordered breathing had higher office diastolic blood pressure and lower mean nocturnal diastolic blood pressure according to 24-hour ambulatory monitoring vs. OSAS patients.
One third of the unaware hypertensive patients have diabetes or renal damage and a high risk of cardiovascular disease
An overall, 29.7% of unaware patients had either kidney damage or diabetes and most of these high risk patients had grade 1 hypertension (66.7 %).
Nephroprotective as well as antihypertensive efficacy of Telmisartan in hypertensives with metabolic disorders
Metabolic effects of telmisartan characterized in significantly decrease level of triglycerides and blood urinary acid level.
The proportional increases of uric acid levels with that in blood pressure
Mean age, mean BMI as also the mean uric acid levels are increasing proportionally with the gradient increasing levels of blood pressure, while the thiazide diuretics give them even greater values.
Correlation between serum uric acid levels and blood pressure at rest and at the peak of exercise amongst newly diagnosed hypertensives
The serum uric acid levels of newly diagnosed untreated hypertensive patients were significantly associated with both SBP/DBP levels at rest and at the peak of exercise, highlighting the potential role of uric acid in the vascular tone changes and reactivity during exercise.
Association of vascular endothelial growth factor with parameters of lipid and carbohydrate metabolism among essential hypertensives
Significantly higher VEGF levels were reported in patients with the high fasting blood glucose levels vs. patients with the normal fasting blood glucose level.
Resistant hypertension amongst adult hypertensives with non-dialysis chronic kidney disease is an inadequately recognized condition
Presence of RH at month 12 was associated with greater risk of end-stage renal disease (ESRD).
Vasodilatory endothelial dysfunction amongst hypertensives in chronic kidney disease
Vasodilatory response in decompression was expressed less than in patients with night-peaker vs. compared with the other groups.
Significant association between Cystatin C and left ventricular hypertrophy in essential hypertensives
significant association Cystatin C with Serum Creatinine and Left ventricular mass index were found at the EH pts
Efficacy of ARB treatment on adiponectin, retinol-binding protein 4 and lipocalin 2 in type 2 diabetics
Increased adiponectin and decreased Retinol-Binding Protein 4 are associated with treatment by telmisartan
Evaluation of the hypertension diagnosis by traditional office blood pressure in the screening of white coat effects
On the basis of a large primary care based sample, people with a diagnostic label of hypertension have a significantly greater white coat effect than those without.
Associations between renal artery variations, renal artery stenosis, impaired renal function, plasma renin activity
Renal artery variations are not associated with higher susceptibility to developing renal artery stenosed lesions and impaired renal function. Moreover, essential hypertensives with aberrant renal arteries are prone to have high plasma renin activity.
 REVIEWS
 
Controversies in the significance of Fractional Flow Reserve Measurement for the Assessment of Coronary Artery Disease
Making a Wise Choice for Enhancing the Success of an unstable PCI Era
Risk Management and New Technologies in Atrial Fibrillation Ablation as the First-line therapy for a Lasting Cure
Chronic Kidney Disease as a New Therapeutic Target in the DES, Valvular and STEMI Era
Prognosis of Hypertrophic Cardiomyopathy
Newer oral anticoagulation therapy for patients with atrial fibrillation
A Coronary Perforation Complicating a PCI is No More Feared: The Dual Catheter rather than Single Catheter Access Technique for a dauntless cardiac intervention
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 INDUSTRY NEWS

CE Mark for OrbusNeich’s COMBO Dual Therapy StentTM, World’s First Dual Therapy Stent for a Delayed Coronary Artery Healing Associated with Monotherapy DES

FDA Approves Merck’s LIPTRUZET (ezetimibe and atorvastatin) as an adjunctive therapy to healthy diet for the lowering of LDL cholesterol in patients with primary or mixed hyperlipidemia

The FDAs approval for an urgent reversal of Warfarin in the treatment of adults with major bleeding is gained by CSL Behring’s Kcentra
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 INTERESTING  CASES
 
A 77 yr old female developed shortness of breath (about 1 yr, recently aggravated) and the symptoms of heart failure, diagnosed with aortic valve stenosis.
Postprocedural catheterization, her pulmonary artery pressure and saturation dramatically decreased from 75% to 91 %. Additionally, her postprocedural TTE displayed a minimal shunt between the LVOT and RV without LVOT obstruction.
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 UPCOMING   EVENTS
 
ESC Congress 2013
August 31, 2013 - September 4, 2013
Amsterdam, Netherlands

 TAG   CLOUD
 
 
 
 
 
 
EuroPCR2013
 
Featured Article

Olmesartan / Amlodipine / Hydrochlorothiazide in Obese Participants With Hypertension : A TRINITY Subanalysis. Featured Article
 
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