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Welcome Oct 31, 2014
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 N E W S C E N T E R
Updated:  Oct 31, 2014
Impact of redefining high platelet reactivity based on specific thresholds for patients with and without DM on MACE post-PCI
Thresholds for platelet reactivity to predict clinical events after coronary intervention are different in patients with and without diabetes mellitus.
Outcomes of prasugrel in CAD patients undergoing elective percutaneous coronary intervention
This study support the risk-benefit profile of an adjusted dosing regimen of prasugrel in patients undergoing PCI.
Correlation between plasma miR-223 and platelet reactivity in CAD patients on dual antiplatelet therapy
More potent platelet inhibition that are associated mainly with newer P2Y12 antagonists, appear to coincide with higher miR-223 when compared to subjects with attenuated responsiveness to DAPT.
 LAST 6 DAYS NEWS
PREFER: Outcomes of person-centred and integrated chronic heart failure and palliative home care
Quality of life and morbidity substantially improve in patients with severe chronic heart failure with person-centred care combined with active heart failure and palliative care at home.
Contribution from individual neck fat compartments to cardiovascular risk
Neck fat compartments expand differently with increasing adiposity, correlate with CVD risk factors, and are associated with metabolic syndrome.
Prognostic impact of QRS prolongation and left bundle branch block, and utilization of cardiac resynchronization therapy in the elderly
Intraventricular conduction delay and left bundle branch block are more commonly present with increasing age.
Impact of rituximab on inflammation, macrovascular and microvascular endothelial function in rheumatoid arthritis patients
Depletion of BCells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.
Predictor of the presence and severity of coronary artery disease and of future adverse events
Elevated plasma levels of soluble urokinase plasminogen activator receptor are associated with CAD presence and severity.
Correlation between renal resistive index and microvascular complications in patients with T2DM
Resistive index may predict the development of microvascular complications in diabetic subjects.
Left Ventricular Diameter and Risk Stratification for Sudden Cardiac Death
Left ventricular diameter may contribute to risk stratification for sudden cardiac death independent of the left ventricular ejection fraction.
Beneficial affects of left atrial roof linear ablation in patients with paroxysmal atrial fibrillation
Atrial fibrillation duration is identified as a covariate associated with arrhythmia recurrence.
Perfusion defect size in patients who underwent serial rubidium-82 positron emission tomography myocardial perfusion imaging
Changes in mild perfusion defects may provide valuable secondary information for evaluation of treatment efficacy in patients who underwent serial MPI.
Effect of mechanical circulatory support on diabetic parameters in patients who underwent left ventricular assist devices implantation
Mechanical circulatory support improves diabetic control in patients with advanced heart failure.
Coronary atheroma regression and plaque characteristics after aerobic exercise
Regular aerobic exercise and optimal medical treatment together induce a moderate regression of necrotic core and plaque burden in IVUS-defined coronary lesions.
Influence of tricyclic and selective-serotonin reuptake inhibitors usage on association between BMI and health risk factors
Selective-serotonin reuptake inhibitors and tricyclic antidepressants use may alter how body weight relates with cardiovascular risk.
Cardiac resynchronization therapy in combination with implantable defibrillator: Effectivity in patients with heart failure and wide QRS duration
Cardiac resynchronization therapy + implantable cardioverter-defibrillator improve survival among Medicare patients meeting class I criteria and among most patients meeting class IIa criteria.
Acute decompensated heart failure that develops after hospital admission
Postadmission onset of ADHF is characterized by differences in co-morbidities and worse short-term prognosis.
Correlation between nonsteroidal anti-inflammatory drug use and atrial fibrillation risk
Nonsteroidal anti-inflammatory drug use is associated with a 12% increased risk for atrial fibrillation incidence.
SEAS Trial: Incidence of cancer and mortality in patients with aortic stenosis on simvastatin and ezetimibe
ezetimibe/simvastatin was not associated with an increased cancer risk or mortality.
PREDIMED study: Impact of dietary glycemic index and glycemic load in all-cause mortality
A high dietary glycemic index increases total mortality in a mediterranean population at high cardiovascular risk.
Correlation between glycemic index, glycemic load, and pulse wave reflection in adults
Glycemic index, glycemic load are directly associated with PAIx75 values in adults without cardiovascular diseases.
Pharmacoinvasive Management of smokers versus non-smokers with ST-Segment Elevation Myocardial Infarction
Current smokers receiving either standard or early invasive management of ST-segment elevation myocardial infarction show more favorable outcomes after fibrinolysis, when compared with non-smokers.
ATHEROREMO-IVUS Study: Correlation between C-reactive protein, coronary plaque characteristics on grayscale, radiofrequency intravascular ultrasound, and cardiovascular outcome in patients with acute coronary syndrome or stable angina pectoris
High-sensitivity CRP is a marker of coronary plaque burden but is not related to the presence of virtual histology-derived thin-cap fibroatheroma lesions and stenotic lesions, in patients who underwent coronary angiography.
eControl Study: Cardiometabolic control in type 2 diabetes based on gender and the presence of cardiovascular disease
LDL-cholesterol levels were remarkably uncontrolled in both women with and women without CVD despite high use of lipid-lowering medications.
Changes in right ventricular (RV) function over time after STEMI and the incidence of RV remodeling
RV function improved early after STEMI, despite the non-negligible incidence of RV remodeling in patients with first STEMI.
MASTER Trial: Efficacy of an Embolic Protection Stent in patients with ST-Segment Elevation Myocardial Infarction
Complete ST resolution after PCI is more frequent in patients with shorter delay to PCI.
Outcomes of Ivabradine in patients with stable coronary artery disease without clinical heart failure
Addition of ivabradine to standard background therapy does not improve outcomes in patients with stable coronary artery disease without clinical heart failure.
Determinants of weight loss in overweight and obese adults
Eating behavior traits and sleep may act together to influence the outcome of weight-loss programs.
Efficacy of statins for preventing contrast-induced acute kidney injury in patients undergoing coronary angiography
Pretreatment with high-dose statins versus low-dose statins or placebo, reduces the incidence of CIAKI, in patients undergoing coronary angiography.
Detecting expression of platelet microRNA among diabetic patients with or without ischemic stroke
Low platelet and plasma miR-223 and miR-146a expression are risk factor for ischemic stroke among diabetics.
Outcomes of ambulance users versus nonusers in ST Elevation Myocardial Infarction patients
Mortality is greater for users despite faster treatment and adjusting for risk.
Risk factor in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
Lower serum triglyceride level is a risk factor for in-hospital and late major adverse events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
Outcomes of Bare-Metal vs. Drug-Eluting Stents in patients with atrial fibrillation undergoing percutaneous coronary intervention
DES use is associated with outcomes comparable to those with BMS without excess bleeding complications.
One-year clinical outcomes of everolimus- versus sirolimus-eluting stents in patients with acute myocardial infarction
Second-generation drug-eluting stent EES has at least comparable or even better safety and efficacy profiles when compared with SES.
Sirolimus systemic exposure and bioresorbable polymer properties of Ultimaster DES in CAD patients
Ultimaster stent leads to almost non-detectable sirolimus in blood after 28 days.
Correlation between endothelial function, cardiovascular risk, and metabolic syndrome in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease in association with non-alcoholic fatty liver disease, further increases the risk of cardiovascular events.
DEFINITION Study: Impact of bifurcation lesions complexity treated with drug-eluting stents
2-stent techniques elicits a lower cardiac death and in-hospital MACE rate for complex lesions but higher rates of in-hospital ST and revascularization at 1 year for simple lesions.
Correlation between hypoglycaemia and QT interval prolongation in T1DM
Insulin induced hypoglycaemia may cause QTc prolongation in patients with T1DM.
Association of levels of irisin with cardio-metabolic variables and insulin sensitivity
High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in nondiabetic adults.
Impact of liraglutide + calorie-restricted diet on lipoprotein profile and CVD risk in overweight/obese prediabetics
Liraglutide therapy plus modest calorie restriction leads to improvement in multiple aspects of lipid/lipoprotein metabolism associated with increased cardiovascular disease (CVD) risk.
Computerized algorithm versus conventional approach for glycemic control in patients undergoing cardiopulmonary bypass
Early computer-based insulin therapy allows better achievement of normoglycemia in patients undergoing major cardiac surgery with the use of blood cardioplegia.
Outcomes of ivabradine treatment in patients with chronic heart failure
Ivabradine treatment for a period over 4 months effectively reduces HR and symptoms in CHF patients.
Correlation between epicardial adipose tissue inflammation and vitamin D deficiency
Epicardial adipose tissue inflammation is related to vitamin D deficiency in patients affected by coronary artery disease.
Association of abdominal fat distribution with atherosclerotic changes in the carotid artery
Total fat area may be considered as a valuable measure of atherosclerotic changes.
The Basque Country Prospective Complications and Mortality Study risk engine (BASCORE)
This validated population-derived model could predict 5-year fatal/non-fatal CHD and CVD risk in patients with newly diagnosed T2DM.
Underlying mechanism by which thiazolidinediones prevent the formation and progression of atherosclerosis and restenosis following percutaneous coronary intervention
Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma.
Linking diabetes mellitus to platelet dysfunction in patients with ST-elevation myocardial infarction
Mean platelet volume has good prognostic value for in-hospital and late mortality among both diabetics and non-diabetics.
Cardiometabolic profile in metabolically healthy obesity and metabolically abnormal obesity
Cardiometabolic risk factors and inflammation in adipose tissue are increased in obese subjects classified as metabolically healthy.
Lipid Profiling for studying the therapeutic effects of metformin and glipizide in T2DM patients with coronary artery disease
Therapeutic effects of metformin and glipizide are different in patients with type 2 diabetes and coronary artery disease and are comparable with their different long-term effects on cardiovascular outcomes.
Correlation between meat intake and indicators of insulin resistance and endothelial function in women
Increased red meat intake is associated with high concentrations of plasma endothelial dysfunction biomarkers in women.
Swedish Heart Failure Registry: Correlation of QRS prolongation and left bundle branch block with age
With increasing age, both left bundle branch block and intraventricular conduction delay are more common.
Significance of left ventricular apical–basal muscle bundle in patients with hypertrophic cardiomyopathy
Apical–basal muscle bundles may represent an additional morphologic marker for HCM diagnosis in genotype-positive status.
Correlation between serum lipoprotein and cardiometabolic risk in middle-aged adults
Low "quotient" Lp(a) concentration mediates autoimmune activation and independently predicts cardiometabolic risk.
Age-related results from the ADDITIONS study
Ivabradine in combination with beta-blocker reduces symptoms and improves quality of life in elderly patients with stable angina pectoris.
Changes in 24 h ambulatory blood pressure and effects of angiotensin II receptor blockade during hypobaric hypoxia
Ambulatory blood pressure increases progressively with increasing altitude, remaining elevated after 3 weeks.
 REVIEWS
Decompensated heart failure
Resistant Hypertension: A challenge for primary care clinicians and specialists
Safety outcomes of aortic valve replacement in aortic stenosis
Fixed-Drug Combinations for an Effective, Treatment Adherence led BP control
Biodegradable Stents or Scaffolds over DESs
Controversies in the significance of Fractional Flow Reserve Measurement for the Assessment of Coronary Artery Disease
Making a Wise Choice for Enhancing the Success of an unstable PCI Era
Risk Management and New Technologies in Atrial Fibrillation Ablation as the First-line therapy for a Lasting Cure
Chronic Kidney Disease as a New Therapeutic Target in the DES, Valvular and STEMI Era
Prognosis of Hypertrophic Cardiomyopathy
Newer oral anticoagulation therapy for patients with atrial fibrillation
A Coronary Perforation Complicating a PCI is No More Feared: The Dual Catheter rather than Single Catheter Access Technique for a dauntless cardiac intervention
  More..

 INDUSTRY NEWS

The WATCHMAN™ Left Atrial Appendage Closure Device receives favorable vote by FDA Advisory Committee Panel

FDA clears 150 cm Length Arrow® GPSCath® Balloon Dilatation Catheters

FDA approves Sorin Group's Solo Smart™ Aortic Pericardial Heart Valve
  More..

 INTERESTING  CASES
 
A 81 year old male patient with a history of hypertension, dyslipidemia, and smoking, presented with a history of chest pain with minimal efforts of two days duration.
Good angiographic result with a TIMI 3 flow was attained. The crush technique was the first choice in the treatment of complex bifurcation lesion of left main.
More..

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Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

 
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