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Welcome Dec 22, 2014
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 N E W S C E N T E R
Updated:  Dec 22, 2014
Release kinetics of inflammatory biomarkers in acute myocardial infarction
IL-6 and neutrophil granulocytes show a continuous rise at all pre-specified time points after induction of myocardial infarction.
Coronary artery disease is the most important factor of survival in charcot neuro-osteoarthropathy patients
In the presence of micro- and macrovascular comorbidities such as retinopathy and peripheral artery disease, the risk to suffer from subsequent amputations during follow-up increases.
Risk of CVD associated with DPP4i in T2DM patients with and without baseline CVD
Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in T2DM patients.
 LAST 6 DAYS NEWS
Detecting masked hypertension
120/82mm Hg is the cutoff of office BP with the best overall operating characteristics for diagnosing masked hypertension.
Impact of Aliskiren on endothelial progenitor cells and vascular function in T2DM patients with essential hypertension
Aliskiren has a favorable effect on endothelial function and EPCs, reduces arterial stiffness, and improves LV twisting and untwisting.
Impact of antihypertensives on Urinary Angiotensin-Converting Enzyme 2 in hypertensive patients
In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary angiotensin-converting enzyme 2 levels.
Correlation between type 2 diabetes and functional outcome of ischemic stroke
Type 2 diabetes is associated with a worse functional outcome of ischemic stroke.
Physicians' Health Study: Correlation between Chocolate consumption and risk of heart failure
Moderate consumption of chocolate might lower the risk of HF in male physicians.
VERITAS study: Worsening heart failure during hospital admission for acute heart failure
Worsening heart failure is associated with delays in discharge and higher rates for readmission and death among patients admitted for AHF.
Prognostic significance of atrial fibrillation in heart failure with a preserved and reduced left ventricular function
Atrial fibrillation is significantly associated with increased mortality in heart failure patients.
Cardiovascular autonomic neuropathy: An independent risk factor for CVD in T1DM patients
Cardiovascular autonomic neuropathy is associated with the presence of other chronic complications in patients with type 1 diabetes.
Predicting 30-day mortality in heart failure patients undergoing non-cardiac surgery
This simple index can accurately identify those at low risk for perioperative mortality among heart failure patients.
Role of milder hyperglycemic states such as prediabetes on CAD
Individuals with prediabetes identified by HbA1c undergoing coronary angiography have worse cardiometabolic profile than those identified by fasting glucose.
Management of spontaneous coronary artery dissection with revascularization versus conservative therapy
Strategy of conservative management with prolonged observation may be preferable to PCI in this patient population.
Outcomes of bare metal stents postdilated with a paclitaxel-eluting balloon versus everolimus-eluting stents
Both DES and BMS+DEB were effective in preventing clinically relevant focal restenosis at 6-month follow-up, despite greater suppression of global neointimal growth in DES.
Relationship between body mass index and bleeding after percutaneous coronary intervention
BMI is associated with increased risk of bleeding and mortality after PCI.
Outcomes of post-discharge statin withdrawal in patients with acute myocardial infarction
Statin withdrawal after AMI leads to significant increase in long-term mortality.
Expected rate of progression and clinical variables associated with accelerated progression in contemporarily managed patients with aortic stenosis
A significant proportion of patients with mild and moderate AS progress to higher grades within the currently recommended time windows for echocardiographic follow-up.
Combining presentation high-sensitivity cardiac troponin I and glucose measurements for ruling out acute myocardial infarction in patients presenting with chest pain to emergency department
Dual testing and LoD approach identify all patients with index AMI.
Association of Insulin-like growth factor-I and insulin-like growth factor binding protein-1 to cardiovascular disease biomarkers in obese adolescents
IGF-I and IGFBP-1 are associated with CVD risk markers and may add to clinical assessments of cardiometabolic dysfunction in youth.
Co-relation between glycated Hhemoglobin A1c, coronary artery calcification and insulin resistance in non-diabetic males
Not only glucose status represented by HbA1c but also insulin resistance may be associated with CAC in non-diabetic men.
Impact of elevated body mass on systemic metabolite profile in early adulthood
Mendelian randomization indicates causal adverse effects of increased adiposity with multiple cardiometabolic risk markers across the metabolite profile in adolescents and young adults in the non-obese weight range.
High salt intake and low blood pressure control rate among hypertensive patients
Patients who consumed less than 6 g/d of salt have a higher control rate.
Association of systolic and diastolic blood pressure changes with myocardial infarction and stroke in CAD patients
BP reduction from baseline over the examined BP range has little effect on the risk of MI and predicts lower risk of stroke among CAD patients initially free from congestive heart failure.
Betaine and Trimethylamine-N-Oxide: Predictive ability of cardiovascular outcomes in diabetes mellitus
Elevated plasma betaine concentration serve as a marker of cardiovascular risk in diabetes.
Early CV prevention in diabetics with mild CKD by GFR criteria alone
Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria.
The Chronic Renal Insufficiency Cohort Study: Blood Pressure and Risk of All-Cause Mortality in Advanced Chronic Kidney Disease and Hemodialysis
Out-of-dialysis-unit SBP is linearly associated with mortality.
Risk of CVD associated with dipeptidyl peptidase-4 inhibitors in T2DM patients with and without baseline CVD
Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in type 2 diabetes.
Long-term safety of nebivolol and valsartan combination therapy in patients with hypertension
Nebivolol and valsartan treatment for a long period of time is safe and well–tolerated in adults with hypertension.
Correlation of elevated 1-h post-load plasma glucose levels with inflammatory profile in subjects with normal glucose tolerance
Value of a 1-h OGTT glucose ≥155 mg/dl may be helpful in identifying a subset of normal glucose tolerance individuals at risk for chronic subclinical inflammation, a predictor of T2DM, and cardiovascular diseases.
ADVANCE: Predicting effects of blood pressure lowering treatment on major cardiovascular events among individual patients with T2DM
A multivariable treatment algorithm can identify individuals who benefit most from blood pressure–lowering therapy in terms of ARR of major adverse cardiovascular events.
Atherosclerosis Risk in Communities Study: Association of high-sensitivity troponin T with cardiovascular events across systolic blood pressure categories
Individuals with lower SBP but measurable troponin T has greater cardiovascular risk compared with those with suboptimal SBP but undetectable troponin T.
Relationship of circulating aldosterone and natriuretic peptides with cardiorenal and metabolic disease in general community
Aldosterone is associated with hypertension, chronic kidney disease, obesity, metabolic syndrome, concentric left ventricular hypertrophy, and lower NPs in the general community.
Long-term efficacy and safety of first-generation drug-eluting stent
1st DES show favorable overall long-term clinical outcome in STEMI patients at the cost of an increased risk of late target lesion revascularization.
Outcomes of bare-metal stenting versus sirolimus-eluting stenting after primary stenting in patients with ST-segment elevated myocardial infarctions in the drug-eluting stent era
BMS did not offset the SES’s angiographic efficacy for primary stenting for STEMI patients.
Correlation between pre-diabetes in overweight youth and early atherogenic risk
Overweight adolescents with pre-diabetes have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, which is moderated by insulin resistance and visceral adiposity.
Relation between components of hemodynamic load and cardiovascular events
There exists an association between higher forward pressure wave amplitude and increased risk for incident CVD.
Correlation between arterial stiffness and insulin treatment mode in T1DM patients
Treatment with continuous subcutaneous insulin infusion is associated with lower arterial stiffness.
Durability of endovascular aortic repair of mycotic aortic aneurysm
Endovascular treatment of mycotic aortic aneurysm is feasible and a durable treatment option for most patients.
Management of patients with residual right-to-left shunt after percutaneous patent foramen ovale closure
A second percutaneous patent foramen ovale occlusion device can be safely implanted in patients with significant residual right-to-left shunt.
Swedish Primary Care Cardiovascular Database (SPCCD): Gender differences in antihypertensive drug treatment
Irrespective of comorbidity, women have higher systolic blood pressures while men report interrupted treatment more often with ACEIs/ARBs.
Impact of amiloride on blood pressure and urine plasminogen activation in patients with treatment–resistant hypertension
Amiloride lowers blood pressure, urine plasminogen excretion and activatio AND albumin/creatinine ratio in patients with hypertension and albuminuria.
TRA 2° P-TIMI 50 Trial: Coronary stent thrombosis with vorapaxar versus placebo
Vorapaxar administered for long-term secondary prevention leads to significant reduction in ARC definite ST, including very late ST, in stable patients with coronary stenting receiving standard antiplatelet therapy.
British Regional Heart Study: Adiposity in early, middle and later adult life and cardiometabolic risk markers in later life
BMI in later life is the dominant influence on cardiovascular and diabetes risks in cohort of men who are thin compared to more contemporary cohorts.
Does hypertension play an important role in the development of cataract
hypertension increased the risk of cataract, especially posterior subcapsular cataract.
Impact of diabetes mellitus and metabolic syndrome on on-clopidogrel platelet reactivity in stable CAD patients undergoing drug-eluting stent placement
Both MS and T2DM were independent predictors of HCPR after clopidogrel loading dose.
Differential effects of age and blood pressure on augmentation index
SBP, but not age, is the significant independent factor influencing the radial AI, in subjects categorized within the highest age tertile, the highest SBP tertile, or the highest radial AI tertile.
Association of chronic hypoxia with blood pressure
Measures of hypoxia are associated with large fluctuations in ambulatory BP, in patients with pneumoconiosis.
Concomitant use of warfarin and ticagrelor versus triple antithrombotic therapy in patients with acute coronary syndrome
Dual antithrombotic therapy and triple antithrombotic therapy are comparable in terms of rates of thrombotic and bleeding events.
Phenotype of resistant hypertension in patients with type 2 diabetes
In patients with T2DM, resistant hypertension is relatively more common.
Role of brachial flow-mediated dilation in predicting subclinical target organ damage progression among essential hypertensives
Flow-mediated dilation can predict future target organ damage progression in low-risk essential hypertensive patients.
 REVIEWS
Decompensated heart failure
Resistant Hypertension: A challenge for primary care clinicians and specialists
Safety outcomes of aortic valve replacement in aortic stenosis
Fixed-Drug Combinations for an Effective, Treatment Adherence led BP control
Biodegradable Stents or Scaffolds over DESs
Controversies in the significance of Fractional Flow Reserve Measurement for the Assessment of Coronary Artery Disease
Making a Wise Choice for Enhancing the Success of an unstable PCI Era
Risk Management and New Technologies in Atrial Fibrillation Ablation as the First-line therapy for a Lasting Cure
Chronic Kidney Disease as a New Therapeutic Target in the DES, Valvular and STEMI Era
Prognosis of Hypertrophic Cardiomyopathy
Newer oral anticoagulation therapy for patients with atrial fibrillation
A Coronary Perforation Complicating a PCI is No More Feared: The Dual Catheter rather than Single Catheter Access Technique for a dauntless cardiac intervention
  More..

 INDUSTRY NEWS

The WATCHMAN™ Left Atrial Appendage Closure Device receives favorable vote by FDA Advisory Committee Panel

FDA clears 150 cm Length Arrow® GPSCath® Balloon Dilatation Catheters

FDA approves Sorin Group's Solo Smart™ Aortic Pericardial Heart Valve
  More..

 INTERESTING  CASES
 
A 81 year old male patient with a history of hypertension, dyslipidemia, and smoking, presented with a history of chest pain with minimal efforts of two days duration.
Good angiographic result with a TIMI 3 flow was attained. The crush technique was the first choice in the treatment of complex bifurcation lesion of left main.
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Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

 
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