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 N E W S C E N T E R
Updated:  Sep 1, 2014
PARADIGM HF: Investigational LCZ696 an angiotensin receptor-neprilysin inhibitor, a new treatment option for heart failure
Advantage of LCZ696 over enalapril on cardiovascular mortality provides strong support for using this new approach instead of ACE inhibitors or ARBs in the treatment of chronic heart failure.
COPPS 2: Colchicine lowers post-pericardiotomy syndrome in patients undergoing cardiac surgery
Patients who take colchicine just before cardiac surgery have a significantly lower risk of developing a common complication called post-pericardiotomy syndrome, with higher side-effects.
POPE 2: Colchicine fails to reduce post-surgical fluid around the heart
The anti-inflammatory drug colchicine is not an effective treatment for cardiac patients who develop a condition called post-operative pericardial effusion (POPE), a build-up of fluid around the heart.
MORE CRT: Quadripolar lead more efficacious than bipolar option in cardiac resynchronisation
Use of a quadripolar left ventricular (LV) lead instead of a bipolar option during cardiac resynchronisation therapy (CRT) can decrease complications at six months.
CONFIRM HF: Improvement in iron deficient heart failure patients with intravenous supplementation
Heart failure patients with iron deficiency can experience significant and sustainable improvements in functional capacity and quality of life and reduced risk of hospital admission for worsening heart failure by receiving just one to two intravenous doses of an iron supplement.
Lipoprotein (a) should be measured to assess global cardiovascular risk as it is a strong predictor of cardiovascular and all-cause mortality in subjects in primary prevention
Impact of statin therapy on low-density lipoprotein cholesterol and triglyceride levels in patients with hypertriglyceridaemia: A VOYAGER meta-analysis
LDL-C reduction is substantial and dependent on the choice and dose of statin, in patients with hypertriglyceridemia.
Preventing contrast-induced nephropathy in diabetic patients with chronic kidney disease undergoing coronary interventions
Single dose administration of erythropoietin prior to coronary angiography or PCI results in trend toward reduction in the incidence of contrast-induced nephropathy.
EURIPE: Glycemic control for kidney injury prevention after PCI
There is an absolute and percentage significant reduction of serum creatinine after PCI in patients with GIK infusion and NAC administration, in addition to ISS.
Long-term clinical outcomes of polytetrafluoroethylene-covered stent implantation in patients with coronary perforation
Coronary perforation during PCI for CTO lesion is not a serious consequence although PCI for CTO has higher risk of coronary perforation.
AMPLIFY trial: Bleeding and thromboembolic risk associated with concomitant use of antiplatelet treatment
Concomitant administration of antiplatelet drugs with apixaban or conventional treatment, produces a proportionally similar increase in the risk of major bleeding, though apixaban is associated with fewer major bleeds, indicating the overall safety benefit of the drug over conventional treatment in patients taking concomitant antiplatelet drugs.
Subclinical left ventricular dysfunction in chronic asymptomatic alcoholics
In chronic alcoholic patients, early functional abnormalities of longitudinal systolic function is observed.
Prognostic value of new parameters derived from cardiopulmonary exercise test beyond the oxygen consumption
Although both peak circulatory power (PCP) and peak oxygen uptake efficiency can identify poorer clinical and functional status in CHF patients, only PCP shows a strong predictive value for major adverse events in this subsets of patients.
Proximal occlusion versus distal filter for cerebral protection during carotid artery stenting
Grade of baseline stenosis and the presence of symptoms may impact the risk of cerebral embolization associated with protected carotid artery stenting.
 LAST 6 DAYS NEWS
Prosthesis-patient mismatch which is highly prevalent in grown-ups with congenital heart disease and aortic valve prosthesis is independently associated with diminished exercise capacity
Impact of diabetes mellitus on patients with ischemic heart failure: Swedish Heart Failure Registry (S-HFR)
Diabetes is an independent predictor of long-term mortality in patients with ischemic heart failure.
Secondary prevention of diabetes mellitus through cardiac rehabilitation
Glucose tolerance test and HbA1c are necessary to decrease underdiagnosis of IGT/ T2DM high risk patients.
TEAMSTA protect I Study: Effect of combination treatment of telmisartan and amlodipine on various cardiovascular biomarkers
Telmisartan with amlodipine and olmesartan with hydrochlorothiazide reduced blood pressure effectively and comparably and also reduced cardiac biomarkers for myocardial ischemia and hemodynamic stress.
Outcomes of clindipine versus amlodipine in patients with essential hyperintension
Clindipine greatly reduced BP and prevented ankle edema unlike amlodipine among newly diagnosed patients with essential hypertension.
Importance of dobutamine dose during stress echocardiography in assessing left ventricular contractile reserve for cardiac resynchronisation therapy
There is no additional benefit of global myocardial contractile reserve determined by high-dose DSE to predict CRT response, when compared to low-dose DSE.
Arterial stiffness derived from wave intensity analysis versus pulmonary arteries distensibility by cardiac magnetic resonance
Pulmonary wave intensity analysis correlates with main pulmonary artery distensibility in patients with or without pulmonary hypertension.
Impact of dipeptidyl peptidase-4 inhibitors on cardiovascular parameters in patients with type 2 diabetes
DPP-4 inhibitors did not significantly reduce cardiovascular death, myocardial infarction, or stroke in patients with type 2 diabetes mellitus or impaired glucose intolerance.
Outcomes of cardiac resynchronization therapy in older patients
Older patients versus younger patients with HF, do not have higher incidence of adverse events and complications after cardiac resynchronization therapy pacemakers system implantation procedure.
Role of osteopontin in vascular complications experienced by patients with type 1 diabetes
Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in T1DM patients.
Pilot European Sentinel Registry: Percutaneous Mitral Valve Edge-to-Edge Repair
Transcatheter mitral valve repair is associated with high immediate success, low complication rates, and sustained 1-year reduction of the severity of mitral regurgitation and improvement of clinical symptoms.
ISAR-ASPI Registry: High on-aspirin treatment platelet reactivity after Percutaneous Coronary Intervention
There exists an association of HAPR, measured at the time point of the PCI, with a higher risk for death or ST during the first year after PCI.
SMART-MR Study: Correlation between metabolic syndrome, prediabetes, and brain abnormalities in patients with manifest arterial disease
There exists an association of presence of MetS with smaller brain volume, in patients with manifest arterial disease and even in patients without diabetes.
Thrombus in patients undergoing transesophageal echocardiography-guided direct current cardioversion after cardiac operations
New thrombus development in patients with atrial arrhythmias early after cardiac operations is not uncommon, especially in patients with heart failure.
Surgical Treatment for Ischemic Heart Failure trial: Surgical ventricular reconstruction in patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery
Among CAD patients with severe regional left ventricular dysfunction, assessment of myocardial viability does not identify patients who derived a mortality benefit from adding surgical ventricular reconstruction to coronary artery bypass graft surgery.
Correlation between presence of microangiopathy and development of hyperglycemia-related cerebral compromise
Ventral striatum is related to cognitive dysfunction in T1DM patients with and without microangiopathy.
Association of rate of weight gain during early adulthood with prevalence of subclinical CAD in recently diagnosed T2D
Greater rate of prior weight gain may accelerate the subclinical vascular complications development in patients with newly diagnosed T2D.
Risk factor for early left ventricular systolic dysfunction following (R)-CHOP chemotherapy in patients with lymphoma
Arterial hypertension confers a significant risk of early LVSD in lymphoma patients treated with (R)-CHOP chemotherapy interfering with its recommended schedule of administration.
Coronary microvascular function and intima-media thickness in patients with preeclampsia
There is impaired coronary flow reserve and increased carotid Iintima-media thickness in patients with preeclampsia.
Impact of telmisartan versus active controls on insulin resistance in hypertensive patients
Telmisartan significantly improves insulin resistance in patients with hypertension.
Impact of renin–angiotensin blocking therapy on abdominal aortic aneurysms in hypertensive patients with normal aorta
RAS blockade given before advancement of aortic medial remodeling may slow down the abdominal aortic aneurysm development.
Effect of statins on coronary flow reserve in systemic hypertensives
Coronary flow reserve is significantly improved after 12 months of rosuvastatin therapy in hypertensive patients at cardiovascular risk and average levels of serum cholesterol.
Predictors of all cause death after transcatheter aortic valve implantation according to gender
Both women and men have the same life expectancy after TAVI, though predictors of adverse events stratified by gender were different.
Action to Control Cardiovascular Risk in Diabetes Study: Impact of glycemic control on incident atrial fibrillation and outcomes
Intensive glycemic control does not have any affect on the rate of new-onset atrial fibrillation.
Association of metabolic syndrome with coronary artery disease based on the presence of diabetes in a symptomatic population
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects.
Malmo preventive project:Correlation between fasting plasma insulin and atrial fibrillation in men
High levels of fasting plasma insulin are associated with lower risk of incident AF in a middle-aged population.
Preventive effect of atorvastatin on atrial fibrillation
Atorvastatin has an overall protective effect against AF, though this preventive effect is not seen in all types of AF.
Cardiovascular structure and function in survivors of severe acute malnutrition
Adult survivors of severe acute malnutrition versus controls have smaller outflow tracts and cardiac output, yet markedly elevated peripheral resistance.
Sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease
Sotalol was associated with increased mortality compared with no AAD but decreased mortality relative to amiodarone.
EVEREST Trial: Use of mineralocorticoid receptor antagonist in hospitalized patients with heart failure, reduced ejection fraction and diabetes mellitus
Among patients hospitalized for worsening heart failure with reduced ejection fraction and co-morbid DM, there was no correlation between discharge MRA use and postdischarge end points.
 REVIEWS
Decompensated heart failure
Resistant Hypertension: A challenge for primary care clinicians and specialists
Safety outcomes of aortic valve replacement in aortic stenosis
Fixed-Drug Combinations for an Effective, Treatment Adherence led BP control
Biodegradable Stents or Scaffolds over DESs
Controversies in the significance of Fractional Flow Reserve Measurement for the Assessment of Coronary Artery Disease
Making a Wise Choice for Enhancing the Success of an unstable PCI Era
Risk Management and New Technologies in Atrial Fibrillation Ablation as the First-line therapy for a Lasting Cure
Chronic Kidney Disease as a New Therapeutic Target in the DES, Valvular and STEMI Era
Prognosis of Hypertrophic Cardiomyopathy
Newer oral anticoagulation therapy for patients with atrial fibrillation
A Coronary Perforation Complicating a PCI is No More Feared: The Dual Catheter rather than Single Catheter Access Technique for a dauntless cardiac intervention
  More..

 INDUSTRY NEWS

FDA approves Sorin Group's Solo Smart™ Aortic Pericardial Heart Valve

FDA clears 150 cm Length Arrow® GPSCath® Balloon Dilatation Catheters

Medtronic announces the positive preliminary results of Micra(TM) Transcatheter Pacing System, the World's Smallest Cardiac Pacemaker
  More..

 INTERESTING  CASES
 
A 81 year old male patient with a history of hypertension, dyslipidemia, and smoking, presented with a history of chest pain with minimal efforts of two days duration.
Good angiographic result with a TIMI 3 flow was attained. The crush technique was the first choice in the treatment of complex bifurcation lesion of left main.
More..

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Featured Article

Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

 
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