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Welcome Sep 19, 2014
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 N E W S C E N T E R
Updated:  Sep 19, 2014
Renal Artery Disease: Prevalence and prognostic significance in patients undergoing coronary bypass grafting
Renal resistive index strongly predicts CV and renal events after CABG, regardless of renal function and other factors.
Predictors of neurologic outcome in patients resuscitated from out-of-hospital cardiac arrest
<1.5 mg of epinephrine and a lactate level <5 mmol/L administration leads to a good neurologic outcome in patients surviving to hospital admission.
Relation of physical activity with glycaemic control and cardiovascular risk profile in Type 2 diabetes
Glycaemic control and cardio-metabolic risk profiles in people with type 2 diabetes are positively related to physical activity.
Cardiac infarction/injury score for identifying subclinical myocardial injury in men and women free of cardiovascular disease
Subclinical myocardial injury among patients without manifestations of CVD is associated with an increased risk of CVD and all-cause mortalities.
 LAST 6 DAYS NEWS
Stenting versus surgical revascularization strategy in patients with non-ST elevation acute coronary syndromes and complex coronary artery disease
At 3-year follow-up, after adjustment for patients' baseline characteristics, immediate stenting compared with surgical revascularization is associated with higher survival probability (87.5 vs 82.8%, HR 1.44, 95% CI 1.2 to 1.7, p <0.01).
ONTARGET and TRANSCEND analysis: Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure
Patients who show improvement to normoalbuminuria over 2 years versus those who deteriorate to microalbuminuria over time, have a lower risk of all-cause and cardiovascular mortality and of cardiovascular and renal events.
Treatment and outcomes of ST segment elevation myocardial infarction and out-of-hospital cardiac arrest on the basis of presence or absence of initial shockable cardiac arrest rhythm
Survival and neurologic outcome in patients with ST-segment elevation myocardial infarctions plus out-of-hospital cardiac arrest, in the absence of an initial shockable rhythm is significantly worse.
HORIZONS-AMI: Impact of pre-procedural cardiopulmonary instability in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
IAE before PCI is an independent predictor of death and identifies a high-risk group in whom faster reperfusion may be particularly important to improve survival.
Greater Dose-Ranging Effects of LX4211 on A1C Levels and Glucosuria in Type 2 Diabetes patients on Metformin Monotherapy
Dual inhibition of SGLT1/SGLT2 with LX4211 results in significant dose-ranging improvements in glucose control and decrease in systolic BP.
FU-Registry: Associations between hypoglycemic agents and clinical outcome of percutaneous coronary intervention among diabetics
Of the hypoglycemic agents, insulin is associated with poor mid-term clinical outcomes in DM patients who underwent PCI, while BG is negatively correlated with MACEs.
Association of nicorandil with all-cause mortality and cardiovascular events in patients with ischemic heart disease
Nicorandil as an adjunct therapy to ischemic heart disease is associated with reduced cardiovascular events.
TRANSFER-AMI: Efficacy of Pharmacoinvasive Management for ST-Segment Elevation Myocardial Infarction in Smokers Versus Non-Smokers
Smoking status does not modify treatment effect on any measured outcomes.
SAVOR - TIMI 53: Correlation between heart failure, saxagliptin and diabetes mellitus
Saxagliptin is associated with an increased risk for hospitalization for heart failure.
Patient Access and Outcomes of Percutaneous Coronary Intervention Facilities with and without On-Site Cardiothoracic Surgery: VA CART Program
Providing PCI facilities without on-site CT surgery improves patient access without comprising procedural or 1-year outcomes.
Impact of short-term continuous positive airway pressure in patients with heart failure and obstructive sleep apnea
Short-term continuous positive airway pressure increases hydroxyephedrine retention in patients with heart failure with reduced ejection fraction and obstructive sleep apnea.
Hybrid Coronary Revascularization: Practice Patterns and Clinical Outcomes
Operative mortality is not statistically significantly associated with either staged hybrid coronary revascularization (HCR) or concurrent HCR in comparison with CABG.
Impact of n-3 FA therapy on triglycerides and flow-mediated dilation in patients with hypertriglyceridemia
Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia.
NOMI - Nitric oxide inhalation in heart attack patients may offer benefit
Inhaled nitric oxide, delivered to heart attack patients before and during treatment with percutaneous coronary intervention does not reduce the extent of damaged tissue (infarct), but may have improved recovery.
Heart and Soul Study: Effect of physical activity level on biomarkers of inflammation and insulin resistance in coronary heart disease
Higher physical activity frequency is independently associated with lower levels of CRP, interleukin-6, and glucose, in outpatients with known CHD.
Association of reduced heart rate variability with pre-clinical cardiovascular disease in T2DM patients
SDNN and SDANN are associated with left ventricular hypertrophy and aortic stiffness.
Long-term follow-up after bariatric surgery in cohorts with adequate retention rates
gastric bypass has better outcomes than gastric band procedures with respect to long-term weight loss, type 2 diabetes control and remission, hypertension, and hyperlipidemi.
FAMOUS-NSTEMI: Diagnostic technique that allows avoidance of surgery in one fifth of heart attacks
FFR measurement, measuring coronary artery blockage in heart attack patients can help more than one fifth of them avoid stents or surgery.
Effect of hyperglycemia and disease duration on cardiac autonomic dysfunction in type 2 diabetes
Elevated blood glucose levels have an unfavorable effect on cardiac autonomic function, which is pronounced in long-term T2DM patients.
ATLANTIC - Ambulance administration of anti-clot drug beneficial in heart attack patients
Ambulance administration of the antiplatelet medication ticagrelor to patients with a type of heart attack known as ST segment elevation myocardial infarction (STEMI) is not better than hospital administration, in terms of improving blood flow in blocked arteries before a revascularisation procedure.
Correlation between sulfonylurea use and incident cardiovascular disease among women with type 2 diabetes
Sulfonylureas when used for long term were associated with a significantly higher risk of developing CHD among women with diabetes.
CvL PRIT: Complete Revascularisation Improves Outcome in Heart Attack Patients
In patients being treated for heart attack, complete revascularisation of all significantly blocked arteries leads to better outcomes compared to a strategy of unblocking just the "culprit" artery responsible for the heart attack.
DDCRT7: Diabetes Distress and Care Registry at Tenri
Serum high-sensitivity C-reactive protein levels are associated with high risk of development, not progression, of diabetic nephropathy among T2DM patients.
STAR AF 2: Optimal method and outcomes of ablation in persistent atrial fibrillation
Freedom from AF recurrence with or without antiarrhythmic medication is comparable with pulmonary vein ablation alone, or when in combination with ablation of atrial regions of the heart or ablation of linear lesions in the left atrium.
SEPTAL CRT: Alternative lead position is safe in cardiac resynchronisation therapy
In heart failure patients undergoing cardiac resynchronisation therapy (CRT), right ventricular (RV) lead placement in the mid-septum as compared to the conventional apical position results in similar outcomes.
Effect of statins on the uptake of glucose analogs by human cells
Statins significantly inhibited the uptake of glucose analogs in human cells.
FOCUS: Fixed-dose combination drug for secondary cardiovascular prevention
Lower medication adherence in secondary prevention following an AMI, is associated with younger age, being depressed and following a complex drug treatment.
RITA-3: 10-year mortality outcome of a routine invasive strategy in patients with non-ST segment elevation acute coronary syndrome
10 year mortality is associated with several baseline variables and varies widely across tertiles of predicted risk.
FAME 2 Primary End-Point Data Analysis: Fractional flow reserve-guided PCI versus medical treatment in patients with stable coronary disease
Fractional flow reserve (FFR)-guided PCI improves outcome as compared with medical treatment, in patients with stable CAD.
SUMO study: Stress echocardiography, a widely available, safe and accurate technique, can be used to detect inducible ischemia in morbidly obese patients
Association of diabetic retinopathy with subclinical myocardial dysfunction in T2DM patients
Microvascular dysfunction contributes to both resting and stress myocardial dysfunction in T2DM patients.
Correlation between coronary flow reserve and contractile reserve in T2DM patients with normal coronary angiography
Reduction of Dip-stress derived longitudinal function when it is still normal at rest, represents an early marker of myocardial dysfunction in DM.
Interleukin 6 gene expression in circulating mononuclear leukocytes of dyslipidemic patients with protective HDL-C levels
Protective HDL-C levels in patients with dyslipidemia are intimately associated with a decreased expression of IL6 in peripheral blood mononuclear cells, even after adjustments in relevant confounding factors.
ENGAGE AF-TIMI 48 Trial: Relationship between Edoxaban dose, Anti-Factor Xa activity, and outcomes
Dose reduction lowered high dose and low dose edoxaban concentrations and anti-FXa levels and preserved efficacy with even greater relative reductions in bleeding when compared with warfarin.
BB-meta-HF: Efficacy of beta-blockers in heart failure patients with atrial fibrillation
In contrast to the beneficial effects observed for those with sinus rhythm, beta-blocker therapy has no or minimal effect on mortality or cardiovascular hospitalisation in HF patients with reduced ejection fraction and AF.
STABILITY trial: Effects of Darapladib in relation to Lp-PLA2 activity levels among CAD patients
Lp-PLA2 activity at baseline did not predict the effects of darapladib treatment on cardiovascular events.
TASTE: One year outcomes do not show any benefit of thrombus aspiration during primary PCI
Thrombus aspiration, as a routine adjunct to primary PCI , does not reduce mortality or ischemic events on long term.
PROTECT: Different late safety profiles with drug-eluting coronary stents with different healing characteristics
Endeavor-ZES reduces the risk of stent thrombosis and the risk of the composite endpoints of death or myocardial infarction when compared to Cypher-SES.
Risk of hypertension six times greater in obese youngsters than normal weights
Risk factor for contrast-induced nephropathy after percutaneous coronary intervention
Metabolic syndrome is a risk factor for contrast-induced nephropathy after percutaneous coronary intervention.
BIOPACE trial: Non-significant trend in favour of biventricular pacing over right ventricular pacing
Biventricular pacing failed to significantly improve outcome compared to right ventricular pacing in patients with atrio-ventricular block.
ANTHEM-HF: Left or right vagus nerve stimulation significantly improves cardiac function
Regulation of the autonomic nervous system with a device that delivers continuous, low-amplitude stimulation to the vagus nerve can significantly improve cardiac function and symptoms in patients with chronic heart failure, regardless of whether the device is implanted on the left or right vagus nerve.
BIOSCIENCE - Experimental coronary stent combines ultrathin structure with biodegradable material
A new generation of coronary artery stent that combines a biodegradable component with an ultrathin scaffold showed promising results compared with the current gold standard, in a large population of coronary artery disease patients.
ANSWER: Clinical benefit of the safer mode in a mixed dual chamber population
SafeR pacemaker mode versus DDD, significantly reduced ventricular pacing in a broad population clinically indicated to dual chamber pacemaker due.
PACE Trial: Long-term data supports the use of biventricular pacing in patients with bradycardia and preserved LV ejection fraction
Biventricular pacing is superior to right ventricular apical pacing in prevention of left ventricular adverse remodeling and deterioration of systolic function.
ADVANCE-ON: Long term effects of blood pressure lowering in patients with type 2 diabetes
Reductions in all-cause death and cardiovascular death recorded during active treatment are sustained to the end of post-trial follow-up, but are diminished.
SYMPLICITY HTN-3: One-year data confirm both the safety and absence of clinical benefit of renal denervation
Renal denervation is safe but resulted in blood pressure reductions similar to a sham procedure.
RELAX AHF trial: Serelaxin reduces in-hospital worsening heart failure
Serelaxin reduces the occurrence of in-hospital worsening heart failure by almost half in patients admitted for acute heart failure.
Body mass index and visceral adipose tissue together act as predictors of cardiovascular risk factors and outcomes
Hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus
When compared to the conventional CABG surgery, hybrid coronary revascularization is associated with less blood product usage and faster recovery.
Platelet reactivity and circulating platelet-derived microvesicles in ACS patients following dual antiplatelet treatment
Elevated levels of circulating platelet-derived microvesicles in patients with high on clopidogrel treatment platelet reactivity indicate ongoing platelet activation despite dual antiplatelet therapy.
POPular Genetics study: Role of CYP2C19 metabolizer status in tailoring antiplatelet strategy in STEMI
A tailored antiplatelet strategy in STEMI patients based on CYP2C19 genotyping is feasible in daily practice.
 REVIEWS
Decompensated heart failure
Resistant Hypertension: A challenge for primary care clinicians and specialists
Safety outcomes of aortic valve replacement in aortic stenosis
Fixed-Drug Combinations for an Effective, Treatment Adherence led BP control
Biodegradable Stents or Scaffolds over DESs
Controversies in the significance of Fractional Flow Reserve Measurement for the Assessment of Coronary Artery Disease
Making a Wise Choice for Enhancing the Success of an unstable PCI Era
Risk Management and New Technologies in Atrial Fibrillation Ablation as the First-line therapy for a Lasting Cure
Chronic Kidney Disease as a New Therapeutic Target in the DES, Valvular and STEMI Era
Prognosis of Hypertrophic Cardiomyopathy
Newer oral anticoagulation therapy for patients with atrial fibrillation
A Coronary Perforation Complicating a PCI is No More Feared: The Dual Catheter rather than Single Catheter Access Technique for a dauntless cardiac intervention
  More..

 INDUSTRY NEWS

FDA clears 150 cm Length Arrow® GPSCath® Balloon Dilatation Catheters

FDA approves Sorin Group's Solo Smart™ Aortic Pericardial Heart Valve

Medtronic announces the positive preliminary results of Micra(TM) Transcatheter Pacing System, the World's Smallest Cardiac Pacemaker
  More..

 INTERESTING  CASES
 
A 81 year old male patient with a history of hypertension, dyslipidemia, and smoking, presented with a history of chest pain with minimal efforts of two days duration.
Good angiographic result with a TIMI 3 flow was attained. The crush technique was the first choice in the treatment of complex bifurcation lesion of left main.
More..

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Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

 
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